Render Target: STATIC
Render Timestamp: 2024-12-26T11:48:30.697Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:58:02.639
Product last modified at: 2024-12-17T19:03:07.677Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

OXR1 (E3D2P) Rabbit mAb #87189

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 139
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    OXR1 (E3D2P) Rabbit mAb recognizes endogenous levels of total OXR1 protein. Based on the sequence of the antigenic peptide, this antibody is expected to detect isoforms 1, 2, 3, 5, and 8 of OXR1.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val180 of human OXR1 protein.

    Background

    Oxidation resistance 1 (OXR1) protein is a cellular oxidative stress sensor that regulates expression of signaling proteins involved in cell cycle arrest and apoptosis (1). Depletion of OXR1 plays a role in oxidative stress associated with neurodegenerative diseases, including Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage (2). OXR1 also plays a role in cell cycle arrest in response to DNA damage (3,4), and is upregulated in cells undergoing senescence (5). OXR1 is a target of the senolytic agent, piperlongumine, and its analogues (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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