Render Target: STATIC
Render Timestamp: 2024-11-22T11:53:35.827Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-10-16 20:01:08.582
Product last modified at: 2024-11-02T17:15:07.966Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PARP2 (F3Z6Z) Rabbit mAb #20009

Filter:
  • WB

    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 66
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:50 - 1:250

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PARP2 (F3Z6Z) Rabbit mAb recognizes endogenous levels of total PARP2 protein.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro318 of human PARP2 protein.

    Background

    Protein ADP-ribosylation plays critical roles in various processes, such as the DNA damage response, chromatin organization, and transcriptional regulation, and is catalyzed by the poly (ADP-ribose) polymerase (PARP) family of proteins (1-3). Namely, PARP1, PARP2, and PARP3 play important roles in the repair of DNA strand breaks (4,5). Growing evidence has shown that PARP2 plays diverse regulatory roles in processes that include genomic stability and cell cycle regulation (6). More specifically, PARP2 has also been shown to contribute to heterochromatin reorganization in endodermal differentiation (7), and loss of PARP2 in mouse erythroid progenitors leads to cell cycle arrest at the G2/M transition (8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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