Name: Parvalbumin Antibody
Price: 302.00 USD
Availability: InStock

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WB

Supporting Data

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	12
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Parvalbumin Antibody recognizes endogenous levels of total parvalbumin protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human parvalbumin protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Parvalbumin (PV, PVALB) is a member of the EF-hand family of calcium-binding proteins, containing EF-hand domains with a high affinity for calcium and magnesium (1). Parvalbumin is expressed in both the soma and in processes of specific subclasses of GABAergic interneurons. Parvalbumin is a slow calcium buffer, meaning it accelerates the initial phase of decay of calcium after an action potential, which likely inhibits facilitation and is thought to regulate short-term synaptic plasticity (2,3). Altered function of PV positive interneurons has been implicated in many neurological diseases, such as Alzheimer’s disease, autism spectrum disorder, schizophrenia, and bipolar disorder (4).

Database Links

UniProt ID: P20472

Entrez-Gene Id: 5816

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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Parvalbumin Antibody #55598