PAX9 (D9F1N) Rabbit mAb #12847
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 38 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
PAX9 is expressed in pharyngeal arch mesenchyme (5,6), and is essential for embryonic development of the teeth and other pharyngeal arch derivatives (5,7). In mice, deletion of PAX9 results in an absence of structures derived from the pharyngeal pouches (e.g. thymus, parathyroid glands) (5), while in humans, PAX9 mutations are frequently associated with congenital tooth agenesis syndromes such as oligodontia and hypodontia (8,9). PAX9 appears to interact with other transcription factors (e.g. MSX1) to regulate the expression of BMP-family proteins (e.g. BMP4) that orchestrate pharyngeal arch development (10,11). Increased expression of PAX9, resulting from amplification at the PAX9 locus, has also been linked in research studies to an increased incidence of lung cancer (12).
- Lang, D. et al. (2007) Biochem Pharmacol 73, 1-14.
- Robson, E.J. et al. (2006) Nat Rev Cancer 6, 52-62.
- Wang, Q. et al. (2008) J Cell Mol Med 12, 2281-94.
- Blake, J.A. et al. (2008) Dev Dyn 237, 2791-803.
- Peters, H. et al. (1998) Genes Dev 12, 2735-47.
- Peters, H. et al. (1998) Eur J Oral Sci 106 Suppl 1, 38-43.
- Hetzer-Egger, C. et al. (2002) Eur J Immunol 32, 1175-81.
- Bergendal, B. et al. (2011) Am J Med Genet A 155A, 1616-22.
- Suda, N. et al. (2011) J Dent Res 90, 382-6.
- Nakatomi, M. et al. (2010) Dev Biol 340, 438-49.
- Wang, Y. et al. (2011) J Dent Res 90, 311-6.
- Kendall, J. et al. (2007) Proc Natl Acad Sci U S A 104, 16663-8.
Limited Uses
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