Render Target: STATIC
Render Timestamp: 2024-11-22T11:45:43.800Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-04-05 20:50:22.487
Product last modified at: 2024-06-27T13:36:05.236Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

PCP4 Antibody #66282

Filter:
  • WB

    Supporting Data

    REACTIVITY M R
    SENSITIVITY Endogenous
    MW (kDa) 12, 15
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PCP4 Antibody recognizes endogenous levels of total PCP4 protein.

    Species Reactivity:

    Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala36 of mouse PCP4 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Purkinje cell protein 4 (PCP4), also known as calmodulin regulator protein and brain-specific polypeptide, is a calmodulin (CaM)-binding protein. PCP4 binds to both calcium-free and calcium-bound CaM (1). PCP4 regulates calmodulin activity and may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling. PCP4 was originally discovered in Purkinje cells of the cerebellum (2). In addition to the cerebellum, PCP4 is expressed in the hippocampus and cortex of the adult rodent brain (3). PCP4 may regulate neurite outgrowth and neurotransmitter release, and its expression levels may be altered in several neurodegenerative diseases, including Alzheimer’s disease (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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