PHGDH Antibody #13428
Inquiry Info. # 13428
Please see our recommended alternatives.
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 57 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Research studies demonstrate that an increase in serine biosynthesis supports growth and proliferation of cancer cells (2-4), which is supported by amplification and overexpression of PHGDH in a subset of melanoma and breast cancers (5,6). Suppression of PHGDH expression in cell lines with elevated PHGDH levels causes a strong decrease in cell proliferation and inhibits tumor growth in vivo (5). Additional evidence suggests that PHGDH interacts with and stabilizes FoxM1, which promotes the proliferation, invasion, and tumorigenicity of glioma cells (7).
- Locasale, J.W. (2013) Nat Rev Cancer 13, 572-83.
- Amelio, I. et al. (2013) Oncogene, [Epub ahead of print].
- Ma, L. et al. (2013) Cell 152, 599-611.
- Maddocks, O.D. et al. (2013) Nature 493, 542-6.
- Possemato, R. et al. (2011) Nature 476, 346-50.
- Locasale, J.W. et al. (2011) Nat Genet 43, 869-74.
- Liu, J. et al. (2013) J Neurooncol 111, 245-55.
Limited Uses
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