Phospho-Jak Family Antibody Sampler Kit #97999
Product Information
Kit Usage Information
Protocols
- 3230: Western Blotting, Immunoprecipitation (Agarose), Immunohistochemistry (Paraffin)
- 3344: Western Blotting, Immunohistochemistry (Paraffin)
- 5031: Western Blotting
- 7074: Western Blotting
- 8082: Western Blotting
- 8827: Western Blotting, Immunoprecipitation (Agarose)
- 14193: Western Blotting, Immunoprecipitation (Agarose)
- 68790: Western Blotting
- 74129: Western Blotting
Product Description
Background
Activation of Jak kinases upon cytokine receptor binding is associated with tyrosine phosphorylation within their activation loops, including Tyr1034/1035 of Jak1, Tyr1007/1008 of Jak2, Tyr980/981 of Jak3, and Tyr1054/1055 of Tyk2. Many studies have indicated that various cytokine receptors have clear preferences that utilize distinct Jak family members. Aberrant regulation of Jak signaling is associated with a number of diseases, including myeloproliferative neoplasms, leukemia, and inflammatory disease (6).
- Leonard, W.J. and O'Shea, J.J. (1998) Annu Rev Immunol 16, 293-322.
- Darnell, J.E. (1997) Science 277, 1630-5.
- VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93.
- Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92.
- Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.
- Babon, J.J. et al. (2014) Biochem J 462, 1-13.
Limited Uses
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