Phospho-LRRK2 (Ser935) Antibody #59576
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Transfected Only |
| MW (kDa) | 290 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Phosphorylation of LRRK2 at Ser910 and Ser935 plays a role in regulating interactions with 14-3-3 protein isoforms. Dephosphorylation of LRRK2 at these sites results in alerted subcellular localization and disrupted interactions with 14-3-3, events notably linked to the presence of five of the six most pathogenic LRRK2 mutations (R1441C, R1441G, R1441H, Y1699C, and I2020T) (6).
- Fahn, S. (2003) Ann. NY Acad. Sci. 991, 1-14.
- Moore, D.J. et al. (2005) Annu. Rev. Neurosci. 28, 57-87.
- Mata, I.F. et al. (2006) Trends Neurosci. 29, 286-293.
- MacLeod, D. et al. (2006) Neuron 52, 587-593.
- Parkinson Study Group. (2004) Neurology 62, 330-332.
- Nichols, R.J. et al. (2010) Biochem J 430, 393-404.
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