Phospho-LSD1 (Ser131) Antibody #37177
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 110 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
LSD1 is phosphorylated by CK2 at Ser131, Ser137, and Ser166 (9). Phosphorylation of LSD1 at Ser131 and Ser137 has been shown to help facilitate RNF168-dependent recruitment to sites of DNA damage (9).
- Shi, Y. et al. (2004) Cell 119, 941-953.
- Wysocka, J. et al. (2006) Nature 442, 86-90.
- Wysocka, J. et al. (2005) Cell 121, 859-872.
- Jacobs, S.A. and Khorasanizadeh, S. (2002) Science 295, 2080-2083.
- Nielsen, P.R. et al. (2002) Nature 416, 103-107.
- Shi, Y.J. et al. (2005) Mol. Cell 19, 857-864.
- Lee, M.G. et al. (2005) Nature 437, 432-435.
- Metzger, E. et al. (2005) Nature 437, 436-439.
- Costa, R. et al. (2014) Biochim Biophys Acta 1844, 722-9.
- Peng, B. et al. (2015) Nucleic Acids Res 43, 5936-47.
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