Phospho-NMDA Receptor 2B (GluN2B) (Ser1303) Antibody #71335
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 190 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Ephrin-B2 binding to its receptor EphB leads to the activation of Src family tyrosine kinases, which phosphorylate NMDAR2B at Tyr1252, Tyr1336, and Tyr1472. In turn, phosphorylated NMDAR2B enhances the ability of the functional NMDA receptor to regulate Ca2+ influx in response to glutamate (7). Phosphorylation of NMDAR2B at Ser1303 has been shown to initiate Ca2+ overload during neuronal excitotoxicity and dephosphorylation at this site may confer neuroprotection (8).
- Liu, X.B. et al. (2004) J Neurosci 24, 8885-95.
- Westphal, R.S. et al. (1999) Science 285, 93-6.
- Tingley, W.G. et al. (1997) J Biol Chem 272, 5157-66.
- Hisatsune, C. et al. (1997) J Biol Chem 272, 20805-10.
- Raman, I.M. et al. (1996) Neuron 16, 415-21.
- Makhinson, M. et al. (1999) J Neurosci 19, 2500-10.
- Takasu, M.A. et al. (2002) Science 295, 491-5.
- Farinelli, M. et al. (2012) PLoS One 7, e34047.
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