Phospho-Scribble (Ser1220) (D8A2) Rabbit mAb #12316
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 240 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The phosphorylation state of Scribble has been shown to be functionally important, in part by regulating subcellular localization (9). Mass spectrometry studies have identified phosphorylation at Ser1220 as a frequent modification in a variety of cell and tissue types (10-13). The functional significance of this modification remains to be elucidated.
- Bilder, D. and Perrimon, N. (2000) Nature 403, 676-80.
- Bilder, D. et al. (2000) Science 289, 113-6.
- Humbert, P.O. et al. (2008) Oncogene 27, 6888-907.
- Sun, Y. et al. (2009) Mol Biol Cell 20, 3390-400.
- Qin, Y. et al. (2005) J Cell Biol 171, 1061-71.
- Navarro, C. et al. (2005) Oncogene 24, 4330-9.
- Takizawa, S. et al. (2006) Genes Cells 11, 453-64.
- Nguyen, M.L. et al. (2003) J Virol 77, 6957-64.
- Yoshihara, K. et al. (2011) Exp Cell Res 317, 413-22.
- Olsen, J.V. et al. (2010) Sci Signal 3, ra3.
- Han, G. et al. (2010) Electrophoresis 31, 1080-9.
- Brill, L.M. et al. (2009) Cell Stem Cell 5, 204-13.
- Wang, Y.T. et al. (2010) J Proteome Res 9, 5582-97.
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