Phospho-SHP-1 (Tyr564) (D11G5) Rabbit mAb #8849
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 68 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
SHP-1 is a substrate of Src family kinases (7,8) and phosphorylation of Tyr564 is thought to be critical for achieving maximal phosphatase activity (8). In a murine model of chronic myelomonocytic leukemia (CMML), genetic suppression of Tyr564 phosphorylation led to constitutive overactivation of the transcription factor Stat5 and an accelerated onset of CMML-like disease (8).
- Yi, T.L. et al. (1992) Mol Cell Biol 12, 836-46.
- Yi, T. et al. (1995) Blood 85, 87-95.
- Keilhack, H. et al. (2001) J Cell Biol 152, 325-34.
- Yi, T. et al. (1993) Mol Cell Biol 13, 7577-86.
- Wu, C. et al. (2003) Gene 306, 1-12.
- Bhattacharya, R. et al. (2008) J Mol Signal 3, 8.
- Zhang, Z. et al. (2003) J Biol Chem 278, 4668-74.
- Xiao, W. et al. (2010) Blood 116, 6003-13.
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