Render Target: STATIC
Render Timestamp: 2024-12-27T12:18:26.335Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-12-24 23:02:06.729
Product last modified at: 2024-12-25T09:00:38.432Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Phospho-STRN (Ser227) (F5B2D) Rabbit mAb #76064

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 105
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Phospho-STRN (Ser227) (F5B2D) Rabbit mAb recognizes transfected levels of STRN protein only when phosphorylated at Ser227.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser227 of human STRN protein.

    Background

    The mammalian striatin family consists of three proteins: Striatin (STRN), Striatin S/G2 nuclear autoantigen (STRN3), and Zinedin (STRN4). It is a component of STRIPAK complexes that function as a scaffold in various signaling pathways (1). The multi-protein STRIPAK complexes play important roles in various biological processes associated with signal transduction pathways, cell division, differentiation, and survival. These complexes have also been linked to several pathological conditions, including cancer, heart disease, diabetes, and neurological diseases. One of the major functions of STRIPAK complexes is to anchor and regulate protein phosphatase 2A (PP2A) activity (2). Phosphorylation of Striatin by ULK1 promotes activation of PP2A and autophagy (3). Striatin is predominantly found in the central and peripheral nervous systems, but its expression can be found in other tissues (4,5). Downregulation of Striatin in motor neurons impaired dendritic growth (6). The STRN gene has been identified as a rare fusion partner with tyrosine kinases PDGFRA and ALK observed in several cancers (7-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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