Phospho-TAB2 (Ser372) (D5A4) Rabbit mAb #8155
- WB
- IP
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80-84 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
TAK1 is associated with TAB1 as well as either TAB2 or TAB3 (9). Activation of TAK1 is triggered by K63-ubiquitination of TRAF6, resulting in binding to TAB2 and TAB3 and autophosphorylation of TAK1 (10-12). Multiple phosphorylation sites have been identified in all three TAB family members that are triggered by IL-1 (13,14). TAB2 phosphorylation was identified at Ser372 and Ser524 (14).
- Yamaguchi, K. et al. (1995) Science 270, 2008-11.
- Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6.
- Shibuya, H. et al. (1996) Science 272, 1179-82.
- Sakurai, H. et al. (2000) FEBS Lett 474, 141-5.
- Takaesu, G. et al. (2000) Mol Cell 5, 649-58.
- Wang, C. et al. (2001) Nature 412, 346-51.
- Ge, B. et al. (2002) Science 295, 1291-4.
- Komatsu, Y. et al. (2002) Mech Dev 119, 239-49.
- Cheung, P.C. et al. (2004) Biochem J 378, 27-34.
- Kishida, S. et al. (2005) Genes Cells 10, 447-54.
- Sato, Y. et al. (2009) EMBO J 28, 3903-9.
- Kanayama, A. et al. (2004) Mol Cell 15, 535-48.
- Cheung, P.C. et al. (2003) EMBO J 22, 5793-805.
- Mendoza, H. et al. (2008) Biochem J 409, 711-22.
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