Phospho-Tau (Ser199) Antibody #29957
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50-80 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Ser199 of Tau is phosphorylated by various kinases such as GSK-3β, AMP-activated protein kinase (AMPK), and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) (4-7). Phosphorylation of Ser199 of Tau is an early event in the pathogenesis of Alzheimer's disease (8,9).
- Johnson, G.V. and Stoothoff, W.H. (2004) J Cell Sci 117, 5721-9.
- Hanger, D.P. et al. (1998) J Neurochem 71, 2465-76.
- Bramblett, G.T. et al. (1993) Neuron 10, 1089-99.
- Qian, W. et al. (2010) J Alzheimers Dis 19, 1221-9.
- Leroy, A. et al. (2010) J Biol Chem 285, 33435-44.
- Thornton, C. et al. (2011) Biochem J 434, 503-12.
- Jin, N. et al. (2015) J Biol Chem 290, 15219-37.
- Mondragón-Rodríguez, S. et al. (2008) Neuropathol Appl Neurobiol 34, 62-75.
- Mondragón-Rodríguez, S. et al. (2008) Int J Exp Pathol 89, 81-90.
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