Phospho-Tau (Thr231/Ser235) (E7G5W) Rabbit mAb #20473
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
It has been shown that phosphorylation of tau at Thr231/Ser235 is elevated in AD brain and human tau-transgenic mouse models of AD, where it may be involved in increasing tau seeding efficiency (4,5). Tau phosphorylation at Thr231 can be detected in cerebrospinal fluid and plasma and shows potential as a biomarker of neurofibrillary pathology in AD (6,7).
- Johnson, G.V. and Stoothoff, W.H. (2004) J Cell Sci 117, 5721-9.
- Hanger, D.P. et al. (1998) J Neurochem 71, 2465-76.
- Bramblett, G.T. et al. (1993) Neuron 10, 1089-99.
- Dujardin, S. et al. (2020) Nat Med 26, 1256-1263.
- Morcinek, K. et al. (2013) Brain Res 1497, 73-84.
- Buerger, K. et al. (2006) Brain 129, 3035-41.
- Ashton, N.J. et al. (2021) Acta Neuropathol 141, 709-724.
Limited Uses
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