Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb #68790
- WB
To Purchase # 68790
| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 68790T | 20 µl | $173 | |
| 68790S | 100 µl | $401 |
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 134 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Related Products
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
The role of Tyk2 has been extensively studied in terms of its involvement in immune regulation and pathological significance (reviewed in 6). Deletion of Tyk2 in mice results in increased sensitivity to infection and defective tumor surveillance, but only a partial effect on Type I interferon signaling (7, 8). In contrast, a human patient diagnosed with hyper-IgE syndrome having increased susceptibility to various microorganisms was found to have a homozygous mutation of Tyk2 (9). These studies suggest a more critical role of Tyk2 in humans with regards to Type I interferon signaling as well as other cytokines including IL-23, IL-6, and IL-10.
- Velazquez, L. et al. (1995) J. Biol. Chem. 270, 3327-34.
- Stahl, N. et al. (1994) Science 263, 92-5.
- Leonard, W.J. (1998) Annu. Rev. Immunol. 16, 293-322.
- Gauzzi, M.C. et al. (1996) J Biol Chem 271, 20494-500.
- Rani, M.R. et al. (1999) J. Biol. Chem. 274, 32507-11.
- Strobl, B. et al. (2011) Front Biosci (Landmark Ed) 16, 3214-32.
- Karaghiosoff, M. et al. (2000) Immunity 13, 549-60.
- Shimoda, K. et al. (2000) Immunity 13, 561-71.
- Minegishi, Y. et al. (2006) Immunity 25, 745-55.
Pathways
Explore pathways related to this product.
Limited Uses
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