Name: PINK1 (D8G3) Rabbit mAb
Price: 139.00 USD
Availability: InStock

Filter:

WB
IP

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	60, 50
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

PINK1 (D8G3) Rabbit mAb recognizes endogenous levels of total PINK1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro140 of human PINK1 protein.

Background

PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria (1-3). PINK1 phosphorylates Parkin and promotes its translocation to mitochondria (2). Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction (1,3).

Database Links

UniProt ID: Q9BXM7

Entrez-Gene Id: 65018

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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PINK1 (D8G3) Rabbit mAb #6946