Render Target: STATIC
Render Timestamp: 2024-12-20T11:28:30.632Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:55:16.688
Product last modified at: 2024-12-17T18:53:48.813Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PLZF (D8G3G) Rabbit mAb #39784

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 80
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PLZF (D83G3) Rabbit mAb recognizes endogenous levels of total PLZF protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val248 of human PLZF protein.

    Background

    PLZF (promyelocytic leukemia zinc finger), is a transcriptional repressor and an epigenetic regulator. It belongs to a large family of BTB-POZ domain containing transcriptional repressors (1). It was first discovered as a fusion partner of RAR (Retinoic Acid Receptor) in the chromosomal translocation t(11; 17) in a case of in acute promyelocytic leukemia (2). PLZF is thought to regulate hematopoietic stem cell quiescence (3,4), maintain spermatogenesis (5), and direct differentiation of distinct populations of natural killer cells (6-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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