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XML generation date: 2024-09-30 01:57:34.716
Product last modified at: 2025-01-01T09:02:27.177Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PML (E6S9L) Rabbit mAb #69789

Filter:
  • IHC
  • IF
Immunohistochemistry Image 1: PML (E6S9L) Rabbit mAb
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using PML (E6S9L) Rabbit mAb.

To Purchase # 69789

Cat. # Size Qty. Price Ships
69789T 20 µl
$162
69789S 100 µl
$357

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 48-200
Source/Isotype Rabbit IgG
Application Key:
  • IHC-Immunohistochemistry 
  • IF-Immunofluorescence 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Immunohistochemistry (Paraffin) 1:500 - 1:2000
Immunofluorescence (Immunocytochemistry) 1:500

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

PML (E6S9L) Rabbit mAb recognizes endogenous levels of total PML protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PML protein.

Background

Promyelocytic leukemia protein (PML) functions via its association with PML bodies in the nucleus (1). PML bodies are dynamic protein aggregates that are interspersed between chromatin in the nuclei of most mammalian cells. The PML protein acts as a scaffold in PML bodies to recruit other proteins, a process regulated by post-translational modifications, such as sumoylation. PML bodies function to regulate a large number of cellular processes, such as tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense (1). The chromosomal translocation t(15;17)(q21;q21) involving the fusion of PML and RARalpha is found in acute promyelocytic leukemia (APL), while a second translocation t(9;15)(p13;q24) involving the fusion of PML and PAX5 was found in acute lymphoblastic leukemia (ALL) (2-6). In addition, PML is frequently inactivated or downregulated in cancer.
For Research Use Only. Not For Use In Diagnostic Procedures.
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