Podoplanin (LpMab-12) Mouse mAb #26981
- IHC
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse IgG1 |
Application Key:
- IHC-Immunohistochemistry
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:125 - 1:500 |
| Flow Cytometry (Fixed/Permeabilized) | 1:400 - 1:1600 |
| Flow Cytometry (Live) | 1:400 - 1:1600 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Podoplanin is O-glycosylated at multiple sites in the extracellular domain, including disialylation at Thr52 in the third platelet-aggregation (PLAG3) domain (10). Research studies have shown that glycoylation at this site is required for tumor cell-induced platelet aggregation activity (11).
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- Breiteneder-Geleff, S. et al. (1999) Am J Pathol 154, 385-94.
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- Omachi, T. et al. (2007) Cancer Lett 246, 167-72.
- Feng, J.Q. et al. (2012) Oral Oncol 48, 848-852.
- Mishima, K. et al. (2006) Acta Neuropathol 111, 563-8.
- Raica, M. et al. Anticancer Res 28, 2997-3006.
- Schoppmann, S.F. et al. (2012) Breast Cancer Res Treat 134, 237-44.
- Ito, M. et al. (2012) Chest 142, 151-158.
- Kato, Y. et al. (2016) PLoS One 11, e0152912.
- Kaneko, M.K. et al. (2007) FEBS Lett 581, 331-6.
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