POMP (D2X9S) Rabbit mAb #15141
- WB
- IP
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 16 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
Proteasome maturation protein (POMP, proteassemblin, hUMP1) is an integral factor essential for assembly of the 20S catalytic core particle during mammalian proteasome biogenesis. POMP promotes heteroheptameric β-ring formation and dimerization of half-proteasomes during core particle assembly. The POMP protein undergoes proteasomal degradation following 20S CP complex assembly and activation (3-6). Research studies suggest that POMP is required for CP assembly for both constitutive proteasomes and immunoproteasomes, and that the assembly focal point resides at the endoplasmic reticulum (6-8). A single nucleotide deletion in the 5' UTR of POMP results in altered epidermal POMP distribution and the autosomal recessive skin disorder known as KLICK syndrome (9).
- Finley, D. (2009) Annu Rev Biochem 78, 477-513.
- Lee, M.J. et al. (2011) Mol Cell Proteomics 10, R110.003871.
- Griffin, T.A. et al. (2000) Mol Cell Biol Res Commun 3, 212-7.
- Witt, E. et al. (2000) J Mol Biol 301, 1-9.
- Ramos, P.C. et al. (1998) Cell 92, 489-99.
- Fricke, B. et al. (2007) EMBO Rep 8, 1170-5.
- Heink, S. et al. (2005) Proc Natl Acad Sci U S A 102, 9241-6.
- Heink, S. et al. (2006) Cancer Res 66, 649-52.
- Dahlqvist, J. et al. (2010) Am J Hum Genet 86, 596-603.
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