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Render Timestamp: 2024-11-21T13:23:01.390Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 02:00:00.069
Product last modified at: 2024-10-18T14:30:10.046Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. POU2F2 (F3B7M) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

POU2F2 (F3B7M) Rabbit mAb #49509

Filter:
  • WB
  • IP
  • IF
  • F

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 51
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200
    Immunofluorescence (Frozen) 1:200 - 1:800
    Immunofluorescence (Immunocytochemistry) 1:100 - 1:400
    Flow Cytometry (Fixed/Permeabilized) 1:800 - 1:3200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    POU2F2 (F3B7M) Rabbit mAb recognizes endogenous levels of total POU2F2 protein. This antibody is predicted to detect multiple human and mouse POU2F2 isoforms.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human POU2F2 protein.

    Background

    POU2F2 (POU domain, class 2, transcription factor 2, OCT2) is a transcription factor in the POU protein family (1-3). POU proteins contain two subunits: an N-terminal POU-specific domain and a C-terminal homeobox domain (1-3). Due to alternate splicing, POU2F2 has five human isoforms and seven mouse isoforms (3). POU2F2 is normally expressed in B cells and B cell lineage tumor cells, and is involved in B cell proliferation and differentiation by binding to immunoglobulin gene promoters (2-4). POU2F2 has also been shown to have a tumor-promoting role in some cancers, as well as potentially promoting oncogene-induced senescence (OIS) escape in early cancer progression (5,6).

    Database Links

    UniProt ID: P09086


    Entrez-Gene Id: 5452


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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