PPM1G (E7J2F) Rabbit mAb #25249
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 72 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
PPM1G (E7J2F) Rabbit mAb recognizes endogenous levels of total PPM1G protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg463 of human PPM1G protein.
Background
Protein phosphatase magnesium/manganese-dependent 1 gamma (PPM1G) is a metal-dependent protein phosphatase belonging to the PP2C/PPM family of Ser/Thr phosphatases. PPM1G is a ubiquitously expressed enzyme that binds magnesium/manganese cations in its active center (1). Research studies have demonstrated that PPM1G acts on numerous substrates to participate in a diverse array of biological processes, such as cell cycle control, protein translation, and antiviral innate immune signaling (2-4). In the context of human disease, PPM1G is highly expressed in hepatocellular carcinoma and may contribute to disease by enhancing cell proliferation and migration (5,6).
- Kamada, R. et al. (2020) Pharmacol Ther 215, 107622.
- Sun, C. et al. (2016) Am J Cancer Res 6, 2207-2220.
- Liu, J. et al. (2013) J Biol Chem 288, 23225-33.
- Yu, K. et al. (2020) Sci Adv 6, eabd0276. doi: 10.1126/sciadv.abd0276.
- Chen, D. et al. (2021) Cell Death Dis 12, 722.
- Xiong, D.L. et al. (2022) Cancer Biomark 34, 13-22.
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