PRMT3 (E9R7B) Rabbit mAb #72593
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 70 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
PRMT3, unlike other Type I PRMTs, is found in the cytoplasm and harbors an N-terminal zinc-finger domain (7,8). It has been found to play a role in ribosome assembly and protein synthesis via binding to RPS2 protein (9). PRMT3 has been shown to regulate LXR activity to increase hepatic lipogenesis (10). Furthermore, PRMT3 has been implicated in cancer due to its ability to stabilize c-Myc (11).
- Bedford, M.T. and Richard, S. (2005) Mol Cell 18, 263-72.
- Pahlich, S. et al. (2006) Biochim Biophys Acta 1764, 1890-903.
- Bedford, M.T. and Clarke, S.G. (2009) Mol Cell 33, 1-13.
- McBride, A.E. and Silver, P.A. (2001) Cell 106, 5-8.
- Gary, J.D. and Clarke, S. (1998) Prog Nucleic Acid Res Mol Biol 61, 65-131.
- Cheng, D. et al. (2007) Mol Cell 25, 71-83.
- Tang, J. et al. (1998) J Biol Chem 273, 16935-45.
- Frankel, A. and Clarke, S. (2000) J Biol Chem 275, 32974-82.
- Swiercz, R. et al. (2005) Biochem J 386, 85-91.
- Nahon, J.E. et al. (2018) Br J Pharmacol 175, 3175-3183.
- Hu, Y. et al. (2021) Gene 791, 145718.
Limited Uses
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