PSMB10/MECL-1 (E6R7O) Rabbit mAb #17579
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 25, 29 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
.
Species Reactivity:
Source / Purification
Background
Proteasome subunit β type-10 (PSMB10, LMP10, MECL-1) is expressed as a proenzyme that is autocleaved to form a mature immunoproteasome core particle subunit (10). Like other immunoproteasome subunits, PSMB10/MECL-1 expression is induced by IFN-γ and subsequent replacement of constitutively expressed PSMB7/Z within the 20S proteasome proteolytic core particle facilitates processing and presentation of MHC class I-restricted peptide antigens on the cell surface (11-13).
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- Nandi, D. et al. (2006) J. Biosci. 31, 137-55.
- Lupas, A. et al. (1993) Enzyme Protein 47, 252-73.
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- Murray, A.W. (2004) Cell 116, 221-34.
- Ciechanover, A. (2006) Proc. Am. Thorac. Soc. 3, 21-31.
- Wang, J. and Maldonado, M.A. (2006) Cell. Mol. Immunol. 3, 255-61.
- Rubinsztein, D.C. (2006) Nature 443, 780-6.
- Groettrup, M. et al. (2010) Nat Rev Immunol 10, 73-8.
- Foss, G.S. et al. (1998) Biochim Biophys Acta 1402, 17-28.
- Hisamatsu, H. et al. (1996) J Exp Med 183, 1807-16.
- Groettrup, M. et al. (1996) Eur J Immunol 26, 863-9.
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