PTPRZ1 (E7C8Z) Rabbit mAb #15641

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Supporting Data

REACTIVITY	H M
SENSITIVITY	Endogenous
MW (kDa)
Source/Isotype	Rabbit IgG

Application Key:

IHC-Immunohistochemistry

Species Cross-Reactivity Key:

H-Human
M-Mouse

Product Information

Product Usage Information

Application	Dilution
Immunohistochemistry (Paraffin)	1:500 - 1:2000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

For a carrier free (BSA and azide free) version of this product see product #19558.

Protocol

Specificity / Sensitivity

PTPRZ1 (E7C8Z) Rabbit mAb detects endogenous levels of total PTPRZ1 protein. Non-specific staining was observed in mouse kidney tubules by immunohistochemistry.

Species Reactivity:

Human, Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PTPRZ1 protein.

Background

PTPRZ1, also known as protein tyrosine phosphatase receptor zeta, is a highly glycosylated membrane protein that is expressed abundantly in normal brain, in a spatially restricted pattern. The functions of PTPRZ1 in neural tissue are thought to be diverse, including development, neural development, neural myelination, and memory formation (1). PTPRZ1 can be found in 2 forms, a membrane-associated glycosylated form and a non-glycosylated, secreted form. In patients with glioma, the soluble form is found to be unregulated in cerebrospinal fluid (2). It is for this and other reports, that PTPRZ1 is a target of pharmaceutical interest. PTPRZ1 has also been reported to be upregulated. Interestingly, increased expression of both membrane bound and soluble PTPRZ1 has also been found in various cancer types, including breast, lung, cervical, hepatocellular carcinoma, and renal tumors (3). In breast cancer, the distribution between localizations of membrane and soluble forms has been reported to change with cancer development, progression, and metastasis.

Database Links

UniProt ID: P23471

Entrez-Gene Id: 5803

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For Research Use Only. Not For Use In Diagnostic Procedures.

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