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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

RalB Antibody #3523

Filter:
  • WB
Western Blotting Image 1: RalB Antibody
Western blot analysis of extracts from various cell types using RalB Antibody.

To Purchase # 3523

Cat. # Size Qty. Price Ships
3523S 100 µl
$306

Supporting Data

REACTIVITY H Mk
SENSITIVITY Endogenous
MW (kDa) 26
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • Mk-Monkey 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

RalB Antibody detects endogenous levels of total RalB protein. The antibody might also react with overexpressed RalA protein.

Species Reactivity:

Human, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu142 of human RalB protein. Antibodies are purified by peptide affinity chromatography.

Background

RalA and RalB are members of the Ras family of small GTPases and are highly homologous in protein sequence. The functions of RalA and RalB are distinct yet overlapping. By binding to various effector proteins, RalA and RalB serve as important GTP sensors for exocytosis and membrane trafficking (1-3). RalA is required for Ras-related tumorigenesis (4) and RalB is important for tumor survival (5). In addition to tumor formation, Ral proteins also play a role in cancer cell migration and metastatic tumor invasion (6,7).
For Research Use Only. Not For Use In Diagnostic Procedures.
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