Render Target: STATIC
Render Timestamp: 2024-12-27T12:12:31.522Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:59:45.644
Product last modified at: 2024-10-24T19:45:08.326Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

RASA2 (F2O1I) Rabbit mAb #36342

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    RASA2 (F2O1I) Rabbit mAb recognizes endogenous levels of total RASA2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Bovine, Pig

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val200 of human RASA2 protein.

    Background

    Ras GTPase-activating protein 2 (RASA2) belongs to the GAP1 subfamily of Ras-GAPs and serves as one of the major Ras-specific GAPs. RASA2 functions to inhibit Ras by facilitating activation of its intrinsic GTPase activity. Similar to other members of the GAP1 subfamily, RASA2 contains calcium-binding C2 domains and a phospholipid binding PH domain (1). Research studies have pointed to RASA2 as an inhibitor of Ras signaling in the context of human cancer, including melanoma (2). More recently, RASA2 has been identified as a negative regulator of T cell effector function through its function as a Ras-specific GAP (3,4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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