Render Target: STATIC
Render Timestamp: 2025-03-14T10:41:52.552Z
Commit: a619ae74f66dae0f27639e88da12bcf600e46428
XML generation date: 2025-03-07 13:08:07.902
Product last modified at: 2025-01-01T09:04:45.938Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

REDD1 Antibody #2516

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 28
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    REDD1 Antibody detects transfected levels of REDD1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Asn60 of human REDD1. Antibodies are purified by peptide affinity chromatography.

    Background

    REDD1 (REgulated in Development and DNA damage responses) expression is induced by hypoxia, cell stress, apoptosis and DNA damage. REDD1 is a transcriptional target of p53 and p63 following DNA damage, and links p63 to Ros (1). REDD1 functions as a negative regulator of mTOR in response to hypoxia in a tuberin-dependent manner (2). Depending on cell context, REDD1 can either be protecting or detrimental for cells under oxidative or ischemic stresses (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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