REG4 Antibody #43411
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 14 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Reg4 is expressed in the gastrointestinal (GI) tract, in normal colon mucosa, and is upregulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease (Crohn’s disease and ulcerative colitis) (4,5).
It has recently been shown that Reg4 marks a population of deep secretory cells at the bottom of the crypts in the colon. In the upper gastrointestinal tract, Paneth cells support the Lgr5+ positive stem cells that reside at the base of deep crypts by providing signals such as Wnt3, EGF, and Notch ligands for stem cell maintenance. No Paneth cells, however, exist in the colon crypts. It is proposed that the Reg4+ population serves as an analogous support system for the LGR5+ positive stem cell population in the colon (1,6).
- Hartupee, J.C. et al. (2001) Biochim Biophys Acta 1518, 287-93.
- Kämäräinen, M. et al. (2003) Am J Pathol 163, 11-20.
- Ho, M.R. et al. (2010) J Mol Biol 402, 682-95.
- Violette, S. et al. (2003) Int J Cancer 103, 185-93.
- Zhang, Y.W. et al. (2003) World J Gastroenterol 9, 2635-41.
- Sasaki, N. et al. (2016) Proc Natl Acad Sci U S A 113, E5399-407.
Limited Uses
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