Regucalcin/SMP30 Antibody #48864
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 33 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Regucalcin/SMP30 Antibody recognizes endogenous levels of total regucalcin/SMP30 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human regucalcin/SMP30 protein. Antibodies are purified by peptide affinity chromatography.
Background
Regucalcin is a highly conserved, multifunctional protein encoded by the RGN gene on the X chromosome, generally recognized as a calcium (Ca2+) binding protein involved in the maintenance of intracellular Ca2+ homeostasis (1). The protein was independently identified and termed Senescence Marker Protein-30 (SMP30), following the observation in a rat aging model that expression of the protein markedly declined with age in a hormone-independent manner (2). Regucalcin/SMP30 has since been implicated in the regulatory control of many fundamental biological processes (e.g., cell growth, apoptosis, cellular metabolism), largely through its role in regulating Ca2+ homeostasis and Ca2+-dependent signal transduction (3-5). Research studies also suggest that regucalcin/SMP30 may function as a tumor suppressor in some contexts (3,6), while serum levels of regucalcin/SMP30 have also been proposed as potential biomarkers of liver and kidney dysfunction (7).
Limited Uses
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