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Product last modified at: 2024-09-13T07:01:04.226Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

RIP2 Antibody #4982

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Filter:
  • WB
Western Blotting Image 1: RIP2 Antibody
Western blot analysis of extracts from 293T cells transfected with RIP2-ΔCARD, and extracts from K562 and MDA-MB-468 cells, using RIP2 Antibody.
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Inquiry Info. # 4982

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Supporting Data

REACTIVITY H M R Mk
SENSITIVITY Endogenous
MW (kDa) 62
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Mk-Monkey 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

RIP2 Antibody detects endogenous levels of total RIP2 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human RIP2. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Receptor Interacting Protein 2 (RIP2) is a serine/threonine kinase with a carboxy-terminal caspase activation and recruitment domain (CARD). Association of RIP2 with the tumor necrosis factor receptor (TNFR) causes activation of NF-κB and induction of apoptosis (1-3). Expression of RIP2 is induced in macrophages upon exposure to bacterial cell wall components, such as LPS. RIP2-deficient mouse models demonstrate that this kinase integrates and transduces signals for both the innate and adaptive immune system (4,5).

Pathways

Explore pathways related to this product.


For Research Use Only. Not For Use In Diagnostic Procedures.
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