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Render Timestamp: 2024-11-21T14:06:59.697Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 02:00:00.739
Product last modified at: 2024-09-30T08:00:33.748Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. ROD1 (E6B2J) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ROD1 (E6B2J) Rabbit mAb #79990

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 48, 58
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ROD1 (E6B2J) Rabbit mAb recognizes endogenous levels of total ROD1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly422 of human ROD1 protein.

    Background

    ROD1, also known as PTBP3, is a member of the polypyrimidine tract-binding (PTB) protein family and a critical RNA-binding factor (1). Characterization of the mRNA and protein isoforms of ROD1 has revealed that alternative splicing surrounding the 5′ end of the gene leads to the generation of eight mRNA and three major protein isoforms. Specifically, alternative translation by re-initiation and leaky scanning through downstream start codons leads to the generation of up to three protein isoforms with varying domains and RNA-binding properties (2). ROD1 has been shown to play functional roles in RNA splicing, translational activation, and mRNA stability and is deregulated in numerous cancers, including breast, gastric, and colorectal cancer (3-6).

    Database Links

    UniProt ID: O95758


    Entrez-Gene Id: 9991


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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