Render Target: STATIC
Render Timestamp: 2024-12-20T12:15:33.293Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-05 20:01:09.746
Product last modified at: 2024-12-17T18:50:50.060Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. SARS-CoV-2 Spike Protein (CR3022 Chimeric) Mouse IgG2a mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SARS-CoV-2 Spike Protein (CR3022 Chimeric) Mouse IgG2a mAb #24387

Filter:
  • ELISA

    Supporting Data

    REACTIVITY Vir
    SENSITIVITY Recombinant
    MW (kDa)
    Source/Isotype Mouse IgG2a
    Application Key:
    • ELISA-ELISA 
    Species Cross-Reactivity Key:
    • Vir-Virus 

    Product Information

    Storage

    Supplied in PBS solution (pH 7.2). Store at –20°C. Avoid repeated freeze-thaw cycles.

    Specificity / Sensitivity

    SARS-Cov-2 Spike Protein (CR3022 Chimeric) Mouse IgG2a mAb recognizes an epitope in the receptor binding domains (RBDs) of SARS-CoV-2 and SARS-CoV spike proteins. SARS-CoV-2 Spike Protein (CR3022 Chimeric) Mouse IgG2a mAb has been reported to bind to both wild-type and P462L-mutant versions of the SARS spike protein. The epitope is only accessible in the "open" conformation of the spike protein (10-13).

    Species Reactivity:

    Virus

    Source / Purification

    Monoclonal antibody was derived from a monoclonal antibody generated semi-synthetically from a patient infected with SARS-CoV (14).

    Background

    The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is similar to other coronaviruses, and is comprised of four key structural proteins: S, the spike protein, E, the envelope protein, M, the membrane protein, and N, the nucleocapsid protein (2). Coronavirus spike proteins are class I fusion proteins and harbor an ectodomain, a transmembrane domain, and an intracellular tail (3,4). The highly glycosylated ectodomain projects from the viral envelope surface and facilitates attachment and fusion with the host cell plasma membrane. The ectodomain can be further subdivided into host receptor-binding domain (RBD) (S1) and membrane-fusion (S2) subunits, which are produced upon proteolysis by host proteases at S1/S2 and S2’ sites. S1 and S2 subunits remain associated after cleavage and assemble into crown-like homotrimers (2,4). In humans, both SARS-CoV and SARS-CoV-2 spike proteins utilize the angiotensin-converting enzyme 2 (ACE2) protein as a receptor for cellular entry (5-7). Spike protein subunits represent a key antigenic feature of coronavirus virions, and therefore represent an important target of vaccines, novel therapeutic antibodies, and small-molecule inhibitors (8,9).

    Database Links

    UniProt ID: P0DTC2


    Entrez-Gene Id: 43740568


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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