Secretagogin (D4V1Y) XP® Rabbit mAb #14037
- WB
- IP
- IHC
- IF
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunohistochemistry (Paraffin) | 1:3200 |
| Immunofluorescence (Frozen) | 1:800 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Secretagogin (SCGN) is a cytosolic calcium-binding protein with homology to calbindin-D28k (CALB1) and calretinin (CALB2). The secretagogin protein was isolated from pancreatic islets of Langerhans and insulinomas, and shows abundant pancreatic expression and reduced expression in thyroid, adrenal medulla, stomach, small intestine, and colon (3). Cloning and sequence analysis of the secretagogin cDNA indicate that the corresponding protein includes six, EF-hand calcium-binding domain tandem repeats (3). Interaction between secretagogin and vesicle trafficking proteins, including SNAP25, SNAP23, ARFGAP2, and DOC2A, suggests a possible role for SCGN in neurotransmitter and hormone release (4,5). Research studies examining secretagogin expression in fetal and developing brains point to a role for this calcium-binding protein in differentiation, brain wiring, and neuronal development (6).
Limited Uses
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