Render Target: STATIC
Render Timestamp: 2024-11-22T10:55:13.914Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-11-19 23:03:08.832
Product last modified at: 2024-11-20T09:00:12.398Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SENP6 (F2K4K) Rabbit mAb #66000

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 150
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SENP6 (F2K4K) Rabbit mAb recognizes endogenous levels of total SENP6 protein. This antibody may detect a band of unknown origin at 80 kDa in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly842 of human SENP6 protein.

    Background

    SUMOylation is a post-translational modification (PTM) that involves the covalent attachment of small ubiquitin-related modifier (SUMO) proteins to substrate proteins. SUMOylation is a reversible process that can be erased by SUMO-specific proteases (SENPs) (1). SENP6 is a critical factor for cell cycle progression and survival (2-4). SENP6 has been shown to deconjugate SUMO2/3 polymers on a group of DNA damage response proteins and is required for maintaining genomic stability (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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