SGK3 Antibody #4227
We recommend the following alternatives
#
Product Name
- WB
- IP
Inquiry Info. # 4227
Please see our recommended alternatives.
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Transfected Only |
| MW (kDa) | 50, 61 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
SGK3 has been shown to be a downstream signaling molecule in the PI3K pathway. Its activation and phosphorylation at Thr320 by PDK1 has been suggested to be an Akt-independent manner of signaling in cancer (8).
- Webster, M.K. et al. (1993) Mol Cell Biol 13, 2031-40.
- Kobayashi, T. and Cohen, P. (1999) Biochem J 339 ( Pt 2), 319-28.
- Park, J. et al. (1999) EMBO J 18, 3024-33.
- Brunet, A. et al. (2001) Mol Cell Biol 21, 952-65.
- Mikosz, C.A. et al. (2001) J Biol Chem 276, 16649-54.
- Hayashi, M. et al. (2001) J Biol Chem 276, 8631-4.
- Brickley, D.R. et al. (2002) J Biol Chem 277, 43064-70.
- Vasudevan, K.M. et al. (2009) Cancer Cell 16, 21-32.
Limited Uses
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