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Product last modified at: 2025-01-01T09:05:57.206Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

SH2D1A (XLP 1D12) Rat mAb #2805

Filter:
  • WB
  • F
Western Blotting Image 1: SH2D1A (XLP 1D12) Rat mAb
Western blot analysis of total cell lysates from Molt4 and Jurkat cells using SH2D1A (XLP 1D12) Rat mAb.

To Purchase # 2805

Cat. # Size Qty. Price
2805T 20 µl
$152
2805S 100 µl
$336

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 14
Source/Isotype Rat IgG2a
Application Key:
  • WB-Western Blotting 
  • F-Flow Cytometry 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Flow Cytometry (Fixed/Permeabilized) 1:400

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

SH2D1A (XLP 1D12) Rat mAb detects endogenous levels of total SH2D1A protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant full-length SH2D1A protein.

Background

SH2D1A and SH2D1B are small, adaptor proteins with a single SH2-domain that play important signal transduction roles mediated by the signaling lymphocytic activation molecule (SLAM) family receptors (1). SH2D1A (also called SAP or SLAM-associated protein) is frequently mutated in patients with X-linked lymphoproliferative disease (Duncan’s disease), which is characterized by extreme susceptibility to Epstein-Barr virus; approximately 50 different SH2D1A mutations have been reported to date (2-4). The single SH2D1B gene in humans (also called EAT-2 or Ewing's sarcoma's/FLI1-activated transcript 2) is present as a pair of duplicated EAT-2A and EAT-2B genes with identical genomic organization in mouse and rat (5,6).
For Research Use Only. Not For Use In Diagnostic Procedures.
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