Render Target: STATIC
Render Timestamp: 2024-12-20T11:23:39.414Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-08-01 15:30:29.161
Product last modified at: 2024-05-30T07:06:31.605Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

SIT Antibody #24201

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 30-40
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SIT Antibody recognizes endogenous levels of total SIT protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro75 of human SIT protein. Antibodies are purified by peptide affinity chromatography.

    Background

    SHP2-interacting transmembrane adapter protein (SIT) is a transmembrane glycoprotein that is expressed in lymphocytes as a disulfide-linked homodimer (1). The cytoplasmic domain of SIT contains multiple tyrosine residues, which when phosphorylated upon TCR engagement, recruit signaling molecules that act to negatively regulate T cell activation (1-3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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