SIX2 Antibody #80170
- WB
Supporting Data
REACTIVITY | H M |
SENSITIVITY | Endogenous |
MW (kDa) | 38 |
SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
SIX2 is functionally important for the development of multiple tissues, notably the kidney, where it has been shown that SIX2 functions downstream of HOXA2 to maintain metanephric mesenchymal progenitors in an undifferentiated state, allowing for self-renewal of renal progenitor cells (8-10). Aberrant expression of SIX2 has likewise been identified as a potential contributing factor in the development of renal malignancies, including Wilms' Tumor (11-13). More recently, SIX2 has been shown to promote the maturation and maintenance of pancreatic beta cells (14,15).
- Kumar, J.P. (2009) Cell Mol Life Sci 66, 565-83.
- Fischbach, K.F. and Technau, G. (1984) Dev Biol 104, 219-39.
- Fischbach, K.F. and Heisenberg, M. (1981) Proc Natl Acad Sci U S A 78, 1105-9.
- Boucher, C.A. et al. (1996) Genomics 33, 140-2.
- Pignoni, F. et al. (1997) Cell 91, 881-91.
- Ford, H.L. et al. (1998) Proc Natl Acad Sci U S A 95, 12608-13.
- Coletta, R.D. et al. (2004) Proc Natl Acad Sci U S A 101, 6478-83.
- Self, M. et al. (2006) EMBO J 25, 5214-28.
- Kutejova, E. et al. (2008) Development 135, 1463-70.
- Kobayashi, A. et al. (2008) Cell Stem Cell 3, 169-81.
- Senanayake, U. et al. (2013) Hum Pathol 44, 336-45.
- Murphy, A.J. et al. (2012) J Pediatr Surg 47, 1239-49.
- Pierce, J. et al. (2014) Transl Oncol 7, 800-11.
- Bevacqua, R.J. et al. (2021) Genes Dev 35, 234-249.
- Velazco-Cruz, L. et al. (2020) Cell Rep 31, 107687.
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