SMARCD3/BAF60C (D6F1S) Rabbit mAb #62265
- WB
- IP
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
SMARCD3/BAF60C is essential for the development of the skeletal and cardiac muscle (10,11). Knockdown of SMARCD3/BAF60C using RNAi in mouse embryos leads to defects in heart development as well as abnormalities in the development of the cardiac and skeletal muscle, mimicking the cardiac defects observed in congenital heart disease (12). In addition, SMARCD3/BAF60C is part of the lipoBAF complex that remodels the chromaitn structure to activate lipogenic genes, promoting lipogenesis in response to feeding and insulin (13).
- Ho, L. and Crabtree, G.R. (2010) Nature 463, 474-84.
- Becker, P.B. and Hörz, W. (2002) Annu Rev Biochem 71, 247-73.
- Eberharter, A. and Becker, P.B. (2004) J Cell Sci 117, 3707-11.
- Bowman, G.D. (2010) Curr Opin Struct Biol 20, 73-81.
- Gangaraju, V.K. and Bartholomew, B. (2007) Mutat Res 618, 3-17.
- Lessard, J.A. and Crabtree, G.R. (2010) Annu Rev Cell Dev Biol 26, 503-32.
- Morettini, S. et al. (2008) Front Biosci 13, 5522-32.
- Wolf, I.M. et al. (2008) J Cell Biochem 104, 1580-6.
- Simone, C. (2006) J Cell Physiol 207, 309-14.
- Puri, P.L. and Mercola, M. (2012) Genes Dev 26, 2673-83.
- Vallaster, M. et al. (2012) Acta Biochim Biophys Sin (Shanghai) 44, 92-102.
- Lickert, H. et al. (2004) Nature 432, 107-12.
- Wang, Y. et al. (2013) Mol Cell 49, 283-97.
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