SOCS1 (E4K7Q) Rabbit mAb #68631
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 23 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
SOCS1 (suppressor of cytokine signaling 1), also known as JAB (Janus Kinase binding protein), SSI-1 (Stat-induced Stat inhibitor-1), and TIP3 (Tec-interacting protein 3) (4-7), is a cytokine-regulated SOCS family member that directly inhibits Jak family members through interaction within their kinase activation loop. In addition to inhibiting Jak/Stat signaling, SOCS1 can also negatively regulate Toll-like receptors that contribute to innate immunity (8,9). The SOCS box of SOCS1 can trigger ubiquitin-mediated degradation of proteins within and outside of the Jak/Stat pathway (10,11). The highest expression of SOCS1 is seen in the thymus and spleen and it plays a critical role in T cell activation and lymphocyte differentiation (4,12). SOCS1 also functions as a tumor suppressor protein by inhibiting hematopoietic oncogenes (13,14).
- Alexander, W.S. et al. (1999) J Leukoc Biol 66, 588-92.
- Chen, X.P. et al. (2000) Immunity 13, 287-90.
- Hilton, D.J. et al. (1998) Proc Natl Acad Sci USA 95, 114-9.
- Starr, R. et al. (1997) Nature 387, 917-21.
- Endo, T.A. et al. (1997) Nature 387, 921-4.
- Naka, T. et al. (1997) Nature 387, 924-9.
- Ohya, K.i. et al. (1997) J Biol Chem 272, 27178-82.
- Kinjyo, I. et al. (2002) Immunity 17, 583-91.
- Davey, G.M. et al. (2006) Tissue Antigens 67, 1-9.
- Kamizono, S. et al. (2001) J Biol Chem 276, 12530-8.
- Rui, L. et al. (2002) J Biol Chem 277, 42394-8.
- Marine, J.C. et al. (1999) Cell 98, 609-16.
- De Sepulveda, P. et al. (1999) EMBO J 18, 904-15.
- Rottapel, R. et al. (2002) Oncogene 21, 4351-62.
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