SOCS3 (D6E1T) Rabbit mAb #52113
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Low levels of SOCS3 are observed in lung, spleen, and thymus and, like other SOCS family members, its expression is rapidly induced by a number of factors including interleukins, EPO, IFN-γ, CSF, and TNF-α (4). SOCS3 uses its SH2 domain to bind activated Jaks and their cognate receptors to provide negative feedback inhibition. In addition to the initially described inducers of SOCS3 expression, subsequent studies have described SOCS3-mediated negative feedback inhibition for leptin (5), GH (6), chemokine receptors (7), insulin (8), and certain pathogens (9,10). SOCS3 deletion results in embryonic lethality with placental insufficiency (11). SOCS3 signaling has been linked pathologically to allergic responses (12), inflammatory disease (13), endotoxic shock (14), wound repair (15), and obesity (16,17).
- Alexander, W.S. et al. (1999) J Leukoc Biol 66, 588-92.
- Chen, X.P. et al. (2000) Immunity 13, 287-90.
- Hilton, D.J. et al. (1998) Proc Natl Acad Sci USA 95, 114-9.
- Starr, R. et al. (1997) Nature 387, 917-21.
- Bjørbaek, C. et al. (1998) Mol Cell 1, 619-25.
- Adams, T.E. et al. (1998) J Biol Chem 273, 1285-7.
- Soriano, S.F. et al. (2002) J Exp Med 196, 311-21.
- Emanuelli, B. et al. (2000) J Biol Chem 275, 15985-91.
- Stoiber, D. et al. (1999) J Immunol 163, 2640-7.
- Stoiber, D. et al. (2001) J Immunol 166, 466-72.
- Roberts, A.W. et al. (2001) Proc Natl Acad Sci U S A 98, 9324-9.
- Seki, Y. et al. (2003) Nat Med 9, 1047-54.
- Shouda, T. et al. (2001) J Clin Invest 108, 1781-8.
- Fang, M. et al. (2005) Cell Mol Immunol 2, 373-7.
- Goren, I. et al. (2006) J Invest Dermatol 126, 477-85.
- Mori, H. et al. (2004) Nat Med 10, 739-43.
- Howard, J.K. et al. (2004) Nat Med 10, 734-8.
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