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Sox10 Antibody #14374

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  • WB
Western blot analysis of extracts from SK-MEL-5 and SK-MEL-28 cells using Sox10 Antibody.
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Inquiry Info. # 14374

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Product Specifications

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 62
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Sox10 Antibody recognizes endogenous levels of total Sox10 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro366 of human Sox10 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

SRY-box 10 (Sox10) is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of cell fate. Sox10 is an important regulator of neural crest and peripheral nervous system development (1-3). Mutations in the SOX10 gene are associated with a group of auditory-pigmentary developmental disorders, including Waardenburg and Waardenburg-Shah syndromes (3,4). Research studies suggest an oncogenic role for Sox10 in various tumor types, such as hepatocellular carcinoma and melanoma (5,6).
For Research Use Only. Not for Use in Diagnostic Procedures.
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