Sox17 (D1T8M) Rabbit mAb #81778
- WB
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Immunocytochemistry) | 1:3200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Transcription factor Sox17 is a Sox family protein with an established role in endoderm specification during development (2). In addition, Sox17 plays essential roles in the maintenance of the hematopoietic stem cell pool (3) and for vascular morphogenesis during development (4,5). Sox17 negatively regulates oligodendrocyte precursor differentiation by antagonizing β-catenin signaling (6). Mutation in the corresponding Sox17 gene in humans is associated with a form of vesicoureteral reflux, a disorder characterized by congenital kidney and urinary tract defects (7).
- Kamachi, Y. and Kondoh, H. (2013) Development 140, 4129-44.
- Engert, S. et al. (2013) Development 140, 3128-38.
- Clarke, R.L. et al. (2013) Nat Cell Biol 15, 502-10.
- Lange, A.W. et al. (2014) Dev Biol 387, 109-20.
- Choi, E. et al. (2012) Stem Cells 30, 2297-308.
- Chew, L.J. et al. (2011) J Neurosci 31, 13921-35.
- Gimelli, S. et al. (2010) Hum Mutat 31, 1352-9.
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