Render Target: STATIC
Render Timestamp: 2024-11-22T10:41:37.581Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:58:56.542
Product last modified at: 2024-09-30T08:02:03.702Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SOX5 (E8S4A) Rabbit mAb #25792

Filter:
  • ChIP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • ChIP-Chromatin Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    For optimal ChIP results, use 2.5 μL of antibody and 10 μg of chromatin (approximately 4 × 106 cells) per IP. This antibody has been validated using SimpleChIP® Enzymatic Chromatin IP Kits.
    Application Dilution
    Chromatin IP 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SOX5 (E8S4A) Rabbit mAb detects endogenous levels of SOX5 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human SOX5 protein.

    Background

    SOX5 is a member of the SOX (SRY-related HMG-box) family of transcription factors. It is involved in the regulation of embryonic development, and specifically essential for driving chondrogenesis (1). In recent years, it has become apparent that SOX5 plays a significant role in the progression of various tumor types, such as breast cancer, glioma, hepatocellular carcinoma, lung cancer, and others (2-5). Upregulation of SOX5 in these tumor types has been reported to drive metastasis through activation of epithelial-mesenchymal transition (EMT) (2-5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    SimpleChIP is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.