Render Target: STATIC
Render Timestamp: 2024-10-30T10:05:25.950Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-08-01 15:28:27.964
Product last modified at: 2024-06-27T13:37:01.624Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

SPON2 Antibody #32823

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 40
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SPON2 Antibody recognizes endogenous levels of total SPON2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu273 of human SPON2 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    SPON2 (spondin 2, mindin) is an extracellular matrix protein belonging to the mindin/F-spondin family (1). The protein has two amino terminal follistatin-like (FS) domains and a carboxy terminal thrombospondin type 1 repeat (TSR) domain. The FS domains mediate interactions between SPON2 and integrins, whereas the TSR domain contributes to the role of SPON2 as a pathogen pattern recognition molecule (2). In that capacity, SPON2 plays an important role in initiation of the innate immune response. It functions as a pattern recognition molecule within the extracellular matrix, where it binds to microbial pathogens and presents them to immune cells (3). Interactions between SPON2 and integrins are also critical for inflammatory cell recruitment and T cell priming (4,5). In addition to its role in innate immunity, SPON2 has also been shown to play a role in hippocampal neuronal outgrowth, cancer metastasis, and diabetic nephropathy (6-8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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