Render Target: STATIC
Render Timestamp: 2025-02-14T12:20:17.938Z
Commit: 7500bcdc731e9059bbdfbdbe9e72caa896e426e8
XML generation date: 2024-08-01 15:28:14.933
Product last modified at: 2025-01-01T09:04:41.668Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

SRSF10 Antibody #42267

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 40
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SRSF10 Antibody recognizes endogenous levels of total SRSF10 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His167 of human SRSF10 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Serine/arginine-rich splicing factor 10 (SRSF10), also known as TASR or SRp38, was initially described as a splicing factor associated with the FUS oncoprotein (1,2). Upon dephosphorylation, SRSF10 represses splicing to regulate numerous functions, including cell cycle, heat shock response, neurogenesis, and adipocyte differentiation (3-6). SRSF10 is affected by adenosine methylation, as it has been shown to be excluded from nuclear speckles by m6A-binding protein YTHDC1 (7). SRSF10 splicing repression has been implicated in colon and cervical cancer (8,9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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