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SRSF10 Antibody #42267

Filter:
  • WB
Western Blotting Image 1: SRSF10 Antibody
Western blot analysis of extracts from various cell lines using SRSF10 Antibody (upper) and α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower).

To Purchase # 42267

Cat. # Size Qty. Price
42267S 100 µl
$306

Supporting Data

REACTIVITY H M R Mk
SENSITIVITY Endogenous
MW (kDa) 40
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Mk-Monkey 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

SRSF10 Antibody recognizes endogenous levels of total SRSF10 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His167 of human SRSF10 protein. Antibodies are purified by peptide affinity chromatography.

Background

Serine/arginine-rich splicing factor 10 (SRSF10), also known as TASR or SRp38, was initially described as a splicing factor associated with the FUS oncoprotein (1,2). Upon dephosphorylation, SRSF10 represses splicing to regulate numerous functions, including cell cycle, heat shock response, neurogenesis, and adipocyte differentiation (3-6). SRSF10 is affected by adenosine methylation, as it has been shown to be excluded from nuclear speckles by m6A-binding protein YTHDC1 (7). SRSF10 splicing repression has been implicated in colon and cervical cancer (8,9).
For Research Use Only. Not For Use In Diagnostic Procedures.
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