Render Target: STATIC
Render Timestamp: 2024-10-30T09:44:04.502Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-20 06:14:11.810
Product last modified at: 2024-08-27T17:45:07.705Z
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

SSTR1 Antibody #11830

Filter:
  • WB

    Supporting Data

    REACTIVITY R
    SENSITIVITY Endogenous
    MW (kDa) 40, 80
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SSTR1 Antibody recognizes endogenous levels of total SSTR1 protein.

    Species Reactivity:

    Rat

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Human, Mouse, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val365 of human SSTR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Somatostatin receptors are part of the super family of G protein-coupled receptors. Five genes encoding six different somatostatin receptor subtypes (SSTR1, SSTR2A, SSTR2B, SSTR3, SSTR4, and SSTR5) have been cloned (1). Somatostatin receptors are activated by somatostatin, a neuropeptide that acts as a neurotransmitter in the brain that regulates hormone secretion from endocrine tissues (2). Somatostatin receptors are found to be highly expressed on human neuroendocrine tumors (3).
    mRNA expression data and immunohistochemical studies indicate high expression of SSTR1 in pituitary and gastroenteropancreatic tumor, renal, colorectal and breast cancer, meningioma, glioma neuroblastoma, and pheochromocytoma (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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